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Psychosis and Schizophrenia

The following Psychosis and Schizophrenia studies are now recruiting in Nottinghamshire Healthcare NHS Foundation Trust.

PATOM - Psychosis, Attention and Theory of Mind.

Principal Investigator: DrEileen O’Regan

Study Summary: An observational study investigating the psychological mechanisms relating to psychosis, such as Theory of Mind. Participants are invited to carry out a number of assessments, which may reveal if these mechanisms are implicated in specific symptoms of psychosis. It is hoped that the findings will lead to increased understanding of psychotic disorders and inform the development of effective interventions.

Inclusion criteria:

  • Psychotic disorder.
  • 18 and over.
  • Clinically stable for > 6 weeks.

Exclusion criteria

  • Psychosis of organic causes, major medical illness, head trauma.
  • Current substance misuse or past substance dependence.
  • Non-English speakers.
  • IQ <70.
  • Lack capacity to provide informed consent.

Lead Research Delivery Officer: Dr Kate Bransby-Adams, This email address is being protected from spambots. You need JavaScript enabled to view it., 07769 235480

PPiP II – Prevalence of Pathogenic antibodies In Psychosis.

Principal Investigator: Dr Eileen O’Regan

Study Summary: An observational study to establish the prevalence of pathogenic antibodies in patients with first episode psychosis. This can help determine whether their positive symptoms are caused by their body’s own immune response rather than a functional illness.

Inclusion criteria:

  • Diagnosis of first episode psychotic illness, or relapse after remission
  • Symptoms in current episode for less than 2 years.
  • Aged 18-70, male or female

Exclusion criteria:

  • Any other neurological disorders
  • Primary drug induced psychosis

Lead Research Delivery Officer: Dr Kate Bransby-Adams, This email address is being protected from spambots. You need JavaScript enabled to view it., 07769 235480

SPRING - The Study of Psychosis and the Role of Inflammation and GABA / Glutamate.

Principal Investigator: Dr Sudheer Lankappa

Study Summary: An observational study investigating the role of brain chemistry in psychosis, specifically glutamate and GABA. Participants are invited to attend a physical health check, followed by two separate MRI scans. This may reveal if these brain chemicals are implicated in the development of psychosis. It is hoped that the findings will lead to increased understanding of psychotic disorders and inform the development of effective interventions.

We are recruiting to 2 groups:

  1. Patients with recent onset psychosis (< 5 years since diagnosis)
  2. Patients with established psychosis (>10 since diagnosis)

Inclusion criteria:

  • Male or female, aged 18 - 55 years.
  • Ability to understand & willing to give written informed consent.
  • English as first language or fluent.
  • Current DSM IV criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder.
  • <5 years from onset (group1) or >10 years onset (group 2).
  • Antipsychotic drugs: no exposure, discontinued or minimal ( <12 weeks) exposure.
  • Normal random blood sugar (the study team will screen for this).
  • Normal blood clotting screen (the study team will screen for this).

Exclusion criteria:

  • A diagnosis of diabetes
  • Relevant clinically significant cardiac disorder such as a cardiac conduction abnormality
  • Clinically significant neurological disorder
  • History of head injury
  • History of thrombosis or thrombophilia
  • Current harmful use of, or recent dependence on, psychoactive substances (excluding nicotine).
  • Contraindications for MR scanning (e.g. claustrophobia, pregnancy etc).

Lead Research Delivery Officer: Dr Kate Bransby-Adams, This email address is being protected from spambots. You need JavaScript enabled to view it., 07769 235480

http://research.bmh.manchester.ac.uk/spring 

Healthy Volunteers Needed.

SPRING are also now recruiting healthy volunteers as a control group. Volunteers will be asked to attend 3 visits which will involve tests of memory and concentration and having two MRI brain scans. A fee will be paid for your time, and travel expenses will be reimbursed.

Inclusion criteria:

  • Aged 18-55
  • No history of psychosis.

Contact Kate Bransby-Adams if you are interested where she will check your eligibility.