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UID:20260825T060652BST-61326Teizb@https://institutemh.org.uk/
DTSTAMP:20260825T050652Z
DESCRIPTION:On the highway to dementia: How early changes in brain connecti
 vity can be a potential biomarker of later disease onset\nDate: Wednesday\
 , 8th December 11.30 a.m. to 12.30 p.m\nSpeaker: Professor Marcus Kaiser\,
  Professor of Neuroinformatics\, Precision Imaging Beacon\, School of Medi
 cine\, University of Nottingham\nPresentation via Microsoft Teams (you mus
 t register to receive the invitation - see below)\nAbstract:\nThe pathophy
 siological process of Alzheimer’s disease is thought to begin years before
  clinical decline\, with evidence suggesting prion-like spreading processe
 s of neurofibrillary tangles and amyloid plaques along fibre tracts across
  the brain. At what point do normal brain connectivity changes in healthy 
 ageing and changes along the path towards dementia differ?\nUsing diffusio
 n magnetic resonance imaging data from the Alzheimer’s Disease Neuroimagin
 g Initiative database\, we first identified relevant features for dementia
  diagnosis. We then created dynamic models with the Nathan Kline Institute
 -Rockland Sample database to estimate the earliest detectable stage associ
 ated with dementia in the simulated disease progression.  A classifier bas
 ed on centrality measures provides informative predictions.  \nStrength an
 d closeness centralities are the most discriminative features\, which are 
 associated with the medial temporal lobe and subcortical regions\, togethe
 r with posterior and occipital brain regions. Our model simulations sugges
 t that changes associated with dementia begin to manifest structurally at 
 early stages. Finally\, I will outline how brain stimulation might provide
  a way to change connectomes. In summary\, our findings suggest that struc
 tural connectivity changes\, observed with diffusion tensor imaging\, can 
 offer a tool for early disease detection before clinical dementia onset.\n
 Please note that you will need to register in order to access the seminar\
 , and you will need to have access to Microsoft Teams.\nTo register your a
 ttendance please email rita.gohil@nottingham.ac.uk  by no later than 9.00 
 a.m. Tuesday 7th December\, to be added to the electronic teams invitation
  list\n  https://institutemh.org.uk/events/event/127-centre-for-dementia-s
 eminar-series
DTSTART:20211208T113000Z
DTEND:20211208T123000Z
LOCATION: ()
SUMMARY:Centre for Dementia Seminar Series
URL:https://institutemh.org.uk/events/event/127-centre-for-dementia-seminar
 -series
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