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UID:20260818T161705BST-6194bieUer@https://institutemh.org.uk/
DTSTAMP:20260818T151705Z
DESCRIPTION:Date: Wednesday 12th October\, 11.30a.m. to 12.30p.m\nOnline vi
 a Microsoft Teams (you must register to receive the invitation - see below
 )\nSpeaker: Dr Mattéa Finelli\nUncovering the redox mechanisms contributin
 g to Alzheimer's disease\nNeurodegenerative diseases represent one of the 
 largest healthcare burdens worldwide and the incidence of these disorders 
 rises with increased life expectancy\; however\, there is currently no dis
 ease-modifying treatment available. Therefore\, it is vitally important\, 
 both for the benefit of patients and societies\, to find effective therapi
 es for these conditions. \nOxidative and nitrosative stresses are cellular
  stresses that arise from the excessive accumulation of reactive oxygen sp
 ecies and reactive nitrogen species produced by the energy metabolism of t
 he cells. Oxidative and nitrosative stresses are well-established contribu
 tors to the neurodegenerative process\, however the underlying mechanims r
 emain unclear. Our group dissects how these stresses affect communication 
 between different cell types in the brain and how they play an active role
  in the selective death of neurons in neurodegenerative conditions.\nUsing
  a combination of advanced proteomics and molecular approaches applied to 
 human stem cell-derived cultures\, we are currently identifying the protei
 ns secreted by cells of the brain to communicate with one another and expl
 ore how these proteins are altered in Alzheimer’s disease. We are explorin
 g how this in turn detrimentally affects cell-cell crosstalk\, function/su
 rvival of neurons\, and ultimately contributing to the pathophysiology of 
 Alzheimer’s disease. The secreted proteins identified will be tested in th
 e future as potential new diagnosis/prognosis biomarkers for Alzheimer’s d
 isease.       \nDr Mattéa Finelli completed her DPhil at the University of
  Oxford (2011). She did a first postdoc at Mount Sinai School of Medicine\
 , New York followed by a second postdoc at the University of Oxford. Over 
 her career\, Mattéa has acquired extensive expertise in a wide range of mo
 lecular and cellular approaches\, animal models\, as well as in transcript
 omics\, metabolomics and proteomics. Mattéa started her own independent re
 search group at the University of Nottingham in January 2020 as an Anne Mc
 Laren Fellow. Her main research focus centers around the role of oxidative
  and nitrosative stresses and redox mechanisms in the pathophysiology of n
 eurodegenerative conditions\, in particular Alzheimer’s disease. Her resea
 rch aims to shed light on the molecular mechanisms of Alzheimer’s disease\
 , and to longer-term open new avenues for translational research on redox-
 based therapeutic approaches to improve health and survival of neurons in 
 this condition.\n \nPlease note that you will need to register in order to
  access the seminar\, and you will need to have access to Microsoft Teams.
 \nTo register your attendance please email toi-fan.choi@nottingham.ac.uk n
 o later than 9.00am Tuesday 11th October 2022\, to be added to the electro
 nic Teams invitation list\n  https://institutemh.org.uk/events/event/146-c
 entre-for-dementia-seminar-series-12th-october
DTSTART:20221012T113000Z
DTEND:20221012T123000Z
LOCATION: ()
SUMMARY:Centre for Dementia seminar series: 12th October 
URL:https://institutemh.org.uk/events/event/146-centre-for-dementia-seminar
 -series-12th-october
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