Current Research

EPIC: Early Psychosis – Investigating Cognition

The Early Psychosis: Investigating Cognition (EPIC) study makes use of functional Magnetic Resonance Spectroscopy (fMRS) to examine real time changes in brain metabolites to study cognitive dysfunction in psychosis.

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SNAPPER: an ADHD and Psychosis/Bipolar disorder trial

The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER

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Epicare graphic, people working in-front of two outlines of heads - one with a scribble inside and one with a lightbulb inside, with graphs and charts around

EPICare: Improving outcomes for people with psychosis through better data and analysis

Clinical effectiveness and implementation evaluation of the Early Psychosis Informatics into Care [EPICare] digital psychosis register and clinical decision support system.

EPICare is a national project developing a digital dashboard and patient registry to help Early Intervention in Psychosis teams track care, treatment and recovery outcomes in real time.

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HEATMAP logo. Rainbow coloured brain in a circle. Heat related gut-microbiota-brain axis changes in psychosis

HEATMAP: Role of heat related gut-microbiota-brain-axis changes in psychosis

HEATMAP is an international study exploring how heat-related changes in the gut-microbiota-brain axis may contribute to new or relapse of psychosis.

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Two researchers in white lab coats, look at a computer screen with data whilst a patient receives a treatment

MRC-Programme: Closed-loop non-invasive stimulation for improving brain and mental health

This MRC-funded programme is developing personalised, non-invasive brain stimulation treatments to improve difficult-to-treat symptoms, cognitive function and quality of life across a range of psychiatric and neurological conditions.

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TITAN-D tools. Computer screens, caps with nodes that transfer data from the brain to the computers

TITAN-D: Temporal Interference Targeted Augmentation of Neuromodulation for Depression - BRC Innovation Fund 2025

This study will investigate whether temporal interference stimulation can prime deeper brain regions to enhance the effects of transcranial magnetic stimulation, supporting the development of more effective, multi-target neuromodulation treatments for depression.

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'adepp' written in a teal circle

ADEPP: Antidepressant For The Prevention Of DEPression Following First Episode Psychosis Trial

ADEPP investigates whether the antidepressant sertraline could prevent depression and support recovery in people following their first episode of psychosis.

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Women having her brain scanned by a TMS figure of 8 tool
Source: Institute Dual Stim Laboratory and credit photo by Alex Wilkinson

TRIDENT: Theta burst stimulation for adolescent depression feasibility study

TRIDENT (Theta buRst stImulation for aDolescent dEpressioN feasibiliTy study) is an NIHR-funded feasibility study exploring whether intermittent theta burst stimulation, a short form of transcranial magnetic stimulation, could be a practical and acceptable treatment option for adolescents with depression. 

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The Home Study

The HOME Study is a national trial exploring whether home-based transcranial direct current stimulation can help improve symptoms of depression alongside usual care. 

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